Patients w/ known CV disease; history of ischemic heart disease, peripheral arterial disease or cerebrovascular disease; significant risk factors for cardiovascular disease eg, HTN, hyperlipidemia & DM. Serious skin adverse events eg, exfoliative dermatitis, SJS & TEN; discontinue upon appearance of skin rash & signs of hypersensitivity. Pregnancy & lactation. Elderly (>65 yr of age).
Coxbitor 400 Increase risk of GI bleeding in concomitant use w/ oral corticosteroids, anticoagulants, longer duration of NSAID therapy, smoking, alcohol & poor general health status. Fluid retention & edema in patients w/ CHF. Severe hepatic reactions including jaundice & fatal fulminant hepatitis, liver necrosis & hepatic failure; not recommended in patients w/ severe hepatic impairment. Long-term administration of NSAIDs may result to renal papillary necrosis. Impaired renal function, heart failure, liver dysfunction, diuretics, ACE-inhibitors, ARBs. Not used to substitute corticosteroid or treat corticosteroid insufficiency. Abrupt discontinuation may lead to exacerbation of corticosteroid-responsive illness. Patients w/ known or poor CYP2C9 metabolizers. Avoid in late pregnancy starting at 30 wk gestation; may cause premature closure of ductus arteriosus.
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